Myelofibrosis

Treosulfan showed superior benefits to busulfan as a conditioning regimen before allogenic hematopoietic stem cell transplantation (allo-HSCT).

Pelabresib, a BET inhibitor, demonstrated meaningful reductions in spleen inflammation and anemia.

Fedratinib is an orally available, small molecule inhibitor of JAK-2 approved for treatment of myelofibrosis.

The findings may offer patients treatment options beyond symptom palliation.

INCA033989 is a monoclonal antibody that selectively targets mutant calreticulin oncogenic function.

Researchers found that PF4/Cxcl4, a key driver of fibrosis, was up regulated on all proteomes.

Luspatercept reduced the need for transfusion in patients with myelofibrosis (MF).

Disease-related factors include several prognostic scoring systems, such as DIPSS, whereas patient-related factors involve age, comorbidities, spleen size, and anemia.

Pharmacists discuss emerging therapies, challenges, and pharmacists’ vital role in myelofibrosis patient care, emphasizing disease-modifying agents and care team collaboration.

Pharmacists discuss tailoring myelofibrosis treatments to individual patient needs, focusing on symptom management, preferences, and challenges in care team collaboration.

Experts discuss patient advocacy, empowering patients in accessing treatments, educating them about health care systems, and collaborating with health care providers for better myelofibrosis management.

It can also help identify patients who would benefit from disease-specific therapies.

Shawn Griffin, PharmD, BCOP, reviews strategies to tackle socioeconomic challenges in myelofibrosis treatment, covering costs, transportation, language barriers, cultural sensitivity, and patient communication.

Robert Mancini, PharmD, and Victoria Nachar, PharmD, discuss strategies and resources for smooth inpatient to outpatient transitions in myelofibrosis care, highlighting medication reconciliation, financial assistance, and the need for dedicated support staff.

Experts discuss obstacles faced while transitioning myelofibrosis patients from inpatient to outpatient care, emphasizing communication, access to medication, and the need for standardized medication reconciliation protocols.

Pharmacists discuss challenges in transitioning myelofibrosis patients between inpatient and outpatient care settings, emphasizing medication reconciliation and seamless inter-team communication.

Pharmacists analyze the role of momelotinib in treating anemia in myelofibrosis, exploring its place in practice and impact on patient care amid emerging therapies.

Pharmacists discuss the impact and alternatives amid red blood cell shortages in myelofibrosis treatment, highlighting challenges, patient outcomes, quality of life issues, and health care cost implications.

Experts discuss the ramifications of red blood cell transfusion shortages on myelofibrosis patient management and delve into the scarcity’s effects, patient prioritization, and the struggle for consistency in care amid supply challenges.

Zahra Mahmoudjafari, PharmD, MBA, BCOP, FHOPA, and a panel of pharmacists explore pharmacist roles in myelofibrosis care, treatment challenges, patient outcomes, and pharmacist responsibilities within interdisciplinary teams.

The model may help clinicians identify patients who would benefit from disease-specific therapies or enrollment into clinical trials.

Expert explains how the role of pharmacists in myelofibrosis treatment has evolved significantly over the past decade.

Ruben A. Mesa, MD, FACP, discusses the results of the SIMPLIFY-1 and MOMENTUM trials and how the data led to the approval of momelotinib to treat intermediate or high-risk myelofibrosis in adult patients with anemia.

Most patients with myelofibrosis will develop anemia over the course of the disease, with more than 30% discontinuing treatment as a result.

Pharmacists also have the resources to help advocate for better care for patients.