According to the investigators, gene changes unique among individuals who responded to mirikizumab indicate that mirikizumab affects a distinct molecular healing pathway when compared to the spontaneous healing that occurred among the cohort administered the placebo.
Study’s secondary endpoints were also met, including the achievement of endoscopic improvement, histologic-endoscopic mucosal improvement, and corticosteroid-free clinical remission at week 52.
Other options for Crohn disease and ulcerative colitis include biologics, corticosteroids, immunosuppressants, and vedolizumab.
Lactitol (Pizensy) is an oral solution for treating chronic idiopathic constipation in adults.
Investigators identified 2 subgroups at risk of developing bacterial biofilms: those who have taken a significant amount of medications over their lifetimes and those who have undergone organ transplants.
Clinicians can play an important role in counseling patients about the 5 main OTC categories of laxatives to treat this gastrointestinal condition.
A combination of 2 bacteria were able to stay in the colon for an extended amount of time, rather than passing through the system quickly like other probiotics.
The approval represents the first and only oral sphingosine 1-phosphate receptor modulator indicated for adults with moderately to severely active ulcerative colitis.
The body’s relationship with gut bacteria emerges after birth and in early infancy, during important immunological and physiological development.
Eating a lot of fat and sugar damage Paneth immune cells in the small intestine, which help regulate flora.
A study published in Nature may document a previously unknown interaction between gut microbes and the thymus, an immune system organ.
When a patient recovering from gonorrhea was fed the powder of the kuchila molung plant, the patient quickly suffered from much more than painful urination.
Models without the Gastrokine-1 protein weigh less and had lower levels of total body fat, despite consuming the same amount of food.
One of the first anti-obesity therapies to be introduced and marketed as a pharmaceutical was 2-4-Dinitrophenol, which entered the market around 1934.
The study investigated whether people who regularly ate higher quantities of nitrate-rich vegetables, such as leafy greens and beetroot, had lower blood pressure.
According to the authors of the study, the findings could lead to new therapies for inflammatory bowel disease and people who've had portions of their bowels removed due to conditions such as colon cancer and ulcerative colitis.
Processed diets may initially reduce the incidence of foodborne infectious diseases, such as E.coli, but might also increase the incidence of diseases characterized by low-grade chronic infection and inflammation.
If gut-imprinted immune cells are diluted in comparison to immune cells triggered by other parts of the body, there could be implications for the oral-based COVID-19 vaccines currently under development.
A greater understanding of obesity and its impact on cardiovascular health highlights abdominal obesity, sometimes referred to as visceral adipose tissue (VAT), as a cardiovascular disease risk marker.
The study authors found there were many different subtypes of goblet cells, and their functions vary more than previously thought.
Nivolumab is the first and only immunotherapy in combination with chemotherapy to deliver superior overall survival compared to chemotherapy alone in this patient population.
The data were presented for the first time at the virtual 2021 American Association for Cancer Research (AACR) Annual Meeting, April 10-15, 2021.
The researchers found that patients who reduced their calorie intake by 10% or more and adopted a moderate exercise program immediately after their diagnosis had, on average, 70% less chance of having lingering leukemia cells after a month of chemotherapy than those not on the diet-and-exercise regimen.
The study did not find significant associations between the intake of unprocessed red meat or poultry with either of these conditions, in contrast to prior studies that linked red meat to higher risks of cardiovascular disease.
The global rise of nonalcoholic fatty-liver disease in pediatric populations has highlighted the need to understand the potential cause of this growing trend.
