Specialty Pharmacy

Top news of the week from Specialty Pharmacy Times

According to results from the CORALLEEN trial presented at the San Antonio Breast Cancer Symposium, neoadjuvant treatment with the cyclin-dependent-kinase (CDK) 4/6 inhibitor ribociclib (Kisqali) and the aromatase inhibitor letrozole (Femara) produced response rates similar to multi-agent chemotherapy in patients with high-risk luminal B breast cancer.

Banu Arun, MD, explains the various reasons for the lack of genetic testing in appropriate candidates. This video was filmed December 12 at the 2019 San Antonio Breast Cancer Symposium.

Oncolytic Viral Therapy (OVT) is currently not recognized by treatment guidelines for advanced pancreatic cancer; however, safety and efficacy data from previous studies conducted over the previous 10 years have shown that OVT may be a promising, innovative approach for patients with pancreatic cancer.

A study found that the total prescriptions for gabapentinoid medications grew from 1.2 million to 3.5 million between 2005-2015.

Abemacilib is an oral selective inhibitor of cyclin-dependent kinases 4 and 6 approved for hormone receptor, human epidermal growth factor receptor 2 metastatic breast cancer.

Enfortumab vedotin-ejfv is the first FDA-approved treatment in the United States for this patient population.

A study sought to determine how HIV avoids the antiviral protein, zinc-finger antiviral protein.

A study evaluated the real-world benefit of palbociclib plus endocrine therapy as a first-line treatment in HR-positive, HER2-negative metastatic breast cancer to correlate the efficacy of the combination with neutropenia.

Patricia Spears discusses the various approaches to discussing clinical trials, and in which situations to use them. This video was filmed December 11 at the 2019 San Antonio Breast Cancer Symposium.

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Researchers have confirmed that the addition of the CDK4/6 inhibitor abemaciclib to aromatase inhibitors is associated with durable tumor responses.

Dawn Hershman, MD, MS, discusses various reasons for non-adherence to endocrine therapy in breast cancer patients. This video was filmed December 13 at the 2019 San Antonio Breast Cancer Symposium.

The EGFR/RAS/MEK pathway may serve as a predictive biomarker for palbociclib plus fulvestrant resistance and offer therapeutic targets to overcome resistance in patients with ER-positive/HER2-negative breast cancer.

Jelly of the Month might not have impressed Clark Griswold, but we're sure there's a pharmacist on your gift list that would appreciate one of these items.

Researchers used an epidermal growth factor (EGF)-conjugated anthrax toxin that, after targeting EGFR, was internalized and triggered apoptosis in exposed bladder cancer cells.

Top news of the day from across the health care landscape.

A retrospective cohort study was the second largest evaluation to date of sodium polystyrene sulphonate use and safety in patients with chronic kidney disease.

The supplemental new drug application approval expands the patient population who stand to benefit from riluzole to include patients with ALS for whom swallowing is difficult and requires the use of percutaneous endoscopic gastrostomy feeding tube.

Top news of the day from across the health care landscape.

In this study, researchers wanted to evaluate the frequency of reduced immunoglobulin concentrations and its association with immunotherapy and disease course in 2 independent cohorts with multiple sclerosis.

The Trend Report is a synthesis of multiple research projects exploring risk factors that influence medication adherence, along with background and implications.

In order to improve the efficacy of checkpoint blockade treatments in patients with breast cancer, it is necessary to consider treatment through the lens of the cancer immunity cycle.

Banu Arun, MD, explains why genetic testing is important and its intended uses for treatment in patients with breast cancer during the 2019 San Antonio Breast Cancer Symposium.

Top news of the week from Specialty Pharmacy Times.

Top news of the day from across the health care landscape.

The etonogestrel/ethinyl estradiol vaginal ring is a flexible birth control used to prevent pregnancy.

Tofacitinib is indicated for the treatment of adult patients with severely active ulcerative colitis, severely active rheumatoid arthritis (RA), or psoriatic arthritis (PsA).

Transform Oncology Care uses results of broad-panel gene sequencing tests to help oncologists identify appropriate treatment regimens based on their patients clinical and genetic profiles.

The study results were presented at the 2019 San Antonio Breast Cancer Symposium, held December 10 through 14.