Specialty Pharmacy

In the pivotal phase 3 KEYNOTE-355 study, pembrolizumab (Keytruda, Merck) combined with chemotherapy met one of its dual primary endpoints of progression-free survival (PFS) as a first-line treatment for patients with metastatic triple-negative breast cancer (TNBC) whose tumors expressed programmed death-ligand 1 (PD-L1).

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New on-demand approach could aid where the absence of pharmacies, physician offices, or basic refrigeration makes it difficult to access critical medicines, daily use chemicals, and other small-molecule compounds.

Although the specialty industry brings a positive impact across quality and continuity of care initiatives, the administration of specialty drugs is highly complex with the number of new therapies and payer requirements.

The DKFZ discovered traces of a total of 23 different virus types in 356 patients with cancer. The most common drivers of tumor initiation and growth were found, including the genome of Epstein-Barr viruses (EBV) and hepatitis B virus (HBV).

WHO Strategy Could End Cervical Cancer Tops SPT Week in Review

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There are 5 available EGFR TKIs for the treatment of patients with EGFR-mutant lung cancers: gefitinib (Iressa), erlotinib (Tarceva), afatinib (Gilotrif), dacomitinib (Vizimpro), and osimertinib.

The Fair Access to Cancer Treatment Act is expected to be signed by Governor Tom Wolf in the near future.

Study findings provide further basis for dietary interventions as future treatments for disorders such as multiple sclerosis.

CAR NK cells are allogenic, which is defined as taking the cells from a non-related healthy donor rather than the patient themselves. Therefore, CAR NK cells have the potential to be manufactured in advance and stored for off-the-shelf immediate use.

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Based on molecular similarities in human and canine diffuse gliomas, researchers have posited that working to cure brain cancer in dogs may lead to improved treatments and even a cure for humans.

Positive results were based on the PROSPER trial, which evaluated the overall survival of enzalutamide plus androgen deprivation therapy versus standard of care.

Capmatinib is an investigational, oral, and selective MET inhibitor, and if approved, it will be the first therapy to specifically target METex14 mutated advanced lung cancer, according to the company.

While KTE-X19 is not yet approved in any country, its Marketing Authorization Application has been validated in the European Union, and its target action date in the United States is August 10, 2020.

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Two studies published in The Lancet have developed models to examine what may happen if the World Health Organization commits to a 3-part strategy to end cervical cancer.

Clinical trials are now evaluating the potential combination of PARP inhibitors with immunotherapy or other agents in patients with ovarian cancer.

Meaningful improvements in outcomes with immunotherapy in recent years are finally starting to change the tide for the first-line treatment of patients with small-cell lung cancer.

Merck has announced its plan to spin-off products from its women's health, trusted legacy brands, and biosimilars into a new, independent, and publicly traded corporation, according to the company.

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Treatment with niraparib resulted in a 38% reduction in the risk of disease progression or death in the overall study population compared with placebo.

Although the prevalence of health system-based specialty pharmacies has grown steadily over the past decade, 2020 will mark a critical year.

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With emerging research from The Sidney Kimmel Cancer Center-Jefferson Health, outcomes in patients with uveal melanoma that has metastasized were shown to significantly improve with changes in treatment.

In addition to safety and tolerability, a pair of clinical studies will evaluate the drug’s efficacy and ability to slow disease progression and to improve quality of life in patients with amyotrophic lateral sclerosis.