Trending News: Patient Characteristics in HCV May Counteract Drug-Drug Interaction Potential in Antiviral Regimens

Adverse childhood experiences could be a predictor of a dementia diagnosis later in life, according to HCP Live. A research team examined the link between adverse childhood experiences and dementia in Japanese adults born before 1948. Investigators assessed dementia onset through the public long-term care insurance system, and adverse childhood experiences included parental death, parental divorce, parental mental illness, family violence, physical abuse, psychological neglect, and psychological abuse.

Investigators have found that changing patient characteristics among those with hepatitis C virus (HCV) may counteract the lower drug-drug interaction potential of modern direct-acting antiviral (DAAs) regimens, according to Contagion Live. The research team evaluated patients with HCV who were treated with DAAs from 2014 to 2018. The findings point to the importance of not underestimating drug-drug interactions in patients with HCV, even with technical improvements in the risk profile of medications.

Total oxidative stress (TOS) and oxidative stress index (OSI) values in saliva may be useful as a diagnostic biomarker for plaque psoriasis, according to The American Journal of Managed Care. Researchers examined salivary parameters in addition to blood in 40 healthy adult patients and 40 patients with plaque psoriasis. They found the saliva was a noninvasive, noninfectious method to measure TOS and OSI in patients who may have plaque psoriasis.