MS Risk Among Relatives Lower Than Expected

Publication
Article
Specialty Pharmacy TimesJan/Feb 2014
Volume 5
Issue 1

Although MS is usually an inherited illness, relatives of patients with the disease may be at a lower risk for developing it than is generally expected, the results of a Swedish study suggest.

Researchers at Sweden’s Karolinska Institute used the Swedish Multiple Sclerosis Registry and a nationwide hospital registry to identify 28,396 patients diagnosed with MS since 1968. Using the Multi-Generation Registry and the Swedish Twin Registry, first- and second-degree relatives and cousins of MS patients were identified and their risk for developing the disease was calculated. These results were then compared with the calculated risks of relatives of a group of individuals without MS. The findings were published online on January 17, 2014, in Brain.

Siblings of MS patients were 7 times more likely to develop MS, while children of MS patients were 5 times more likely to inherit the disease compared with those without a family history of the disease. However, grandchildren and nieces and nephews of MS patients did not have an increased risk for developing the disease compared with the general population.

“[O]ur findings suggest a theoretically smaller number of multiple sclerosis risk genes, indicating that a greater proportion of the genes contributing to multiple sclerosis susceptibility have been identified than previously thought,” the authors of the study conclude.

Related Videos
Human brain digital illustration. Electrical activity, flashes, and lightning on a blue background. | Image Credit: Siarhei - stock.adobe.com
© 2024 MJH Life Sciences

All rights reserved.