Chiasma recently presented data at the annual meeting of The Endocrine Society that show Octreolin (oral octreotide) reduced pituitary growth hormone secretion in healthy volunteers as effectively as shown in published studies of injectable octreotide.
Chiasma, a privately held biopharma company, recently presented data at the annual meeting of The Endocrine Society (ENDO 2012) that show Octreolin, an investigational new oral drug being developed for use in acromegaly, reduced pituitary growth hormone secretion in healthy volunteers as effectively as shown in published studies of injectable octreotide, with similar safety, pharmacokinetic and pharmacodynamic profiles.
Octreolin is an oral formulation of injectable octreotide, a somatostatin analog with proven efficacy and safety that is commercially available only by injection. While acromegaly is a treatable disease, management with injectable somatostatin analogs can result in injection-site pain and sub-optimal quality-of-life issues for patients during lifelong treatment.
"We are pleased to report these results indicating that our investigational oral product Octreolin could potentially be effective as a twice-daily medication to suppress growth hormone for treatment of acromegaly," said Chiasma Chief Medical Officer,
, MD. "We hope to confirm these findings in patients with acromegaly in our ongoing phase 3 trial, the results of which are expected in mid-2013."
Highlights from the data presented at ENDO include:
"These data presented at ENDO 2012 and accepted for publication in the Journal of Clinical Endocrinology and Metabolism, along with our preclinical and toxicology results, enabled Chiasma to launch a global phase 3 trial this past March," said Roni Mamluk, PhD, Chiasma's chief operating officer. "This program represents the first initiative to bring patients a possible oral alternative to injectable somatostatin analogs, which could provide them with freedom from injections by a healthcare provider."
SOURCE: PR Newswire