Daily Medication Pearl: Umbralisib (Ukoniq)

Article

Umbralisib (Ukoniq) is indicated for the treatment of adult patients with relapsed or refractory marginal zone lymphoma and relapsed or refractory follicular lymphoma.

Medication Pearl of the Day: Umbralisib (Ukoniq)

Indication: Umbralisib (Ukoniq) is a kinase inhibitor indicated for the treatment of adult patients with relapsed or refractory marginal zone lymphoma (MZL) who have received at least 1 prior anti-CD20-based regime and for adult patients with relapsed or refractory follicular lymphoma who have received at least 3 prior lines of systemic therapy.


Insight:

  • Dosing: Recommended dosage 800 mg orally once daily with food.
  • Dosage forms:Tablets 200 mg.
  • Adverse events: The most common (≥15%) adverse reactions—including laboratory abnormalities—were increased creatinine, diarrhea-colitis, fatigue, nausea, neutropenia, transaminase elevation, musculoskeletal pain, anemia, thrombocytopenia, upper respiratory tract infection, vomiting, abdominal pain, decreased appetite, and rash.
  • Mechanism of action: Umbralisib inhibits multiple kinases. In biochemical and cell-based assays, umbralisib inhibited PI3Kδ and casein kinase CK1ε. PI3Kδ is expressed in normal and malignant B-cells; CK1ε has been implicated in the pathogenesis of cancer cells, including lymphoid malignancies.
  • Manufacturer: TG Therapeutics

Sources:

label (fda.gov)

ukoniq image - Google Search

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