Daily Medication Pearl: Tofacitinib (Xeljanz)

Xeljanz can be used for rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and polyarticular course juvenile idiopathic arthritis.

Medication Pearl of the Day: Tofacitinib (Xeljanz)

Indication: Xeljanz can be used for rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and polyarticular course juvenile idiopathic arthritis.

Insight:

  • Dosing: Xeljanz 5 mg twice daily or Xeljanz XR 11 mg once daily up to 22 mg per day.
    • Dosage form:
      • Xeljanz tablets: 5 mg, 10 mg
      • Xeljanz XR Tablets: 11 mg, 22 mg
      • Xeljanz oral solution: 1 mg/mL
  • Adverse events (AEs): Most common AEs are upper respiratory tract infection, nasopharyngitis, diarrhea, headache, and herpes zoster.
  • Mechanism of action: Xeljanz is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes that transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function.
  • Manufacturer: Pfizer

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