Daily Medication Pearl: Efgartigimod alfa-fcab (Vyvgart)

Efgartigimod alfa-fcab (Vyvgart) is a human immunoglobulin G1 antibody fragment indicated for the treatment of generalized myasthenia gravis.

Medication Pearl of the Day: Efgartigimod alfa-fcab (Vyvgart)

Indication: Efgartigimod alfa-fcab (Vyvgart)is a neonatal Fc receptor blocker indicated for the treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor antibody positive.

Insight:

  • Dosing: The recommended dosage is 10 mg/kg administered as an intravenous infusion over 1 hour once weekly for 4 weeks.
  • Dosage forms: Injection 400 mg in 20 mL (20 mg/mL) single-dose vial.
  • Adverse events: Most common adverse reactions (≥ 10%) in patients treated with gMG are respiratory tract infections, headache, and urinary tract infection.
  • Mechanism of action: Efgartigimod alfa-fcab is a human immunoglobulin G1 (IgG1) antibody fragment that binds to the neonatal Fc receptor, resulting in the reduction of circulating IgG.
  • Manufacturer: Argenx

Sources:

vyvgart-prescribing-information.pdf (argenx.com)

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