Combo Treatment Effectively Cures Hepatitis C in Liver Transplant Recipients

Article

Study shows the safety and efficacy of treatment with sofosbuvir and velpatasvir in adults with recurrent chronic genotypes 1-4 HCV infection after liver transplant.

Patients with hepatitis C virus (HCV) infection who receive a liver transplant typically experience disease recurrence that can damage the transplanted liver. In a new study, researchers evaluated the safety and efficacy of treatment with sofosbuvir and velpatasvir (SOF/VEL) in adults with recurrent chronic genotype 1-4 HCV infection after liver transplant.

SOF/VEL is a combination therapy approved for patients with chronic HCV. To determine whether the treatment effectively cured HCV after liver transplantation, patients were treated with SOF/VEL 400/100 mg daily and evaluated for sustained virologic response rates 12 weeks after treatment (SVR12).

For the study, a total of 79 patients with genotype 1-4 HCV infection were enrolled and treated. Eighty-one percent of patients were men, 82% were white, 18% had compensated cirrhosis, and 59% were treatment experienced, according to the study.

The researchers found that treatment with SOF/VEL produced high SVR12 and demonstrated no clinically relevant drug interactions with immunosuppressants. Commonly used immunosuppressants included tacromilus (71%), mycophenolic acid (24%), and cyclosporine (14%), and azathioprine (11%). Ninety-six percent of patients were cured of HCV infection following 3 months of treatment with SOF/VEL.

By genotype, SVR12 rates were 95% for genotype 1, 100% for genotype 2, 97% for genotype 3, and 100% for genotype 4.

Of the patients treated, 2 experienced virologic relapse: 1 with genotype 1a infection was non-cirrhotic and treatment naïve and 1 with genotype 3 infection was non-cirrhotic and treatment experienced. One patient discontinued treatment with SOF/VEL due to hyperglycemia, but no serious or severe adverse events were found to be related to treatment. Additionally, no liver transplant rejection episodes or deaths occurred during the study period.

Overall, treatment with SOF/VEL for 12 weeks was found to be highly effective and well tolerated in transplant recipients with HCV infection with and without cirrhosis. Patients experiencing recurring HCV infection following a liver transplant can benefit from the combination treatment without any drug interactions with immunosuppressive therapy, according to the study authors.

Reference

Agarwal K, Castells L, Müllhaupt B, et al. Sofosbuvir/velpatasvir for 12 weeks in genotype 1-4 HCV-infected liver transplant recipients. Journal of Hepatology. 2018. Doi: https://doi.org/10.1016/j.jhep.2018.05.039

Related Videos
male pharmacist using digital tablet during inventory in pharmacy | Image Credit: sofiko14 - stock.adobe.com
Pharmacist holding medicine box in pharmacy drugstore. | Image Credit: I Viewfinder - stock.adobe.com
Pharmacy Drugstore Checkout Cashier Counter | Image Credit: Gorodenkoff - stock.adobe.com
Medicine tablets on counting tray with counting spatula at pharmacy | Image Credit: sutlafk - stock.adobe.com
Capsules medicine and white medicine bottles on table | Image Credit: Satawat - stock.adobe.com
Human cell or Embryonic stem cell microscope background | Image Credit: Anusorn - stock.adobe.com
Concept of health care, pharmaceutical business, drug prices, pharmacy, medicine and economics | Image Credit: Oleg - stock.adobe.com
Biosimilar pharmaceutical drug bottle on blue background. | Image Credit: Carl - stock.adobe.com
Pharmaceutical manufacture background with glass bottles with clear liquid on automatic conveyor line. | Image Credit: wacomka - stock.adobe.com
Bottle and scattered pills on color background, top view | Image Credit: New Africa - stock.adobe.com
© 2024 MJH Life Sciences

All rights reserved.