Chromosome Screening Could Improve IVF Success Rates in Chromosomal Polymorphism Carriers


Higher incidence of chromosomal polymorphisms in infertile individuals.

Variants in chromosomal polymorphisms was found to have an impact on fertility by increasing aneuploidies in male gametes and embryos, according to a recent study.

Published in Systems Biology in Reproductive Medicine, the findings showed an increase in the frequency of polymorphic variants among infertile patients compared with fertile donors. The results suggest its impact on fertility.

Additional findings showed that female polymorphism carriers had a higher risk for embryo aneuploidy compared with females with a normal karyotype. Prior research has shown a higher incidence of chromosomal polymorphisms in infertile patients, but the relationship between infertility and these variants remains unclear.

“The application of a comprehensive chromosome screening to select euploid embryos could improve IVF success rates among chromosomal polymorphism carriers,” said study co-author Ruth Morales. “One may consider withdrawing donated oocytes with polymorphic variants from the donation program, and analyzing the rate of sperm aneuploidy in sperm donors carrying a polymorphism.”

Related Videos
Catalyst Trial, Diabetes, Hypertension | Image Credit: grinny -
male pharmacist using digital tablet during inventory in pharmacy | Image Credit: sofiko14 -
Pharmacist holding medicine box in pharmacy drugstore. | Image Credit: I Viewfinder -
Pharmacy Drugstore Checkout Cashier Counter | Image Credit: Gorodenkoff -
Medicine tablets on counting tray with counting spatula at pharmacy | Image Credit: sutlafk -
Capsules medicine and white medicine bottles on table | Image Credit: Satawat -
Human cell or Embryonic stem cell microscope background | Image Credit: Anusorn -
© 2024 MJH Life Sciences

All rights reserved.