Chromosome Screening Could Improve IVF Success Rates in Chromosomal Polymorphism Carriers

Variants in chromosomal polymorphisms was found to have an impact on fertility by increasing aneuploidies in male gametes and embryos, according to a recent study.

Published in Systems Biology in Reproductive Medicine, the findings showed an increase in the frequency of polymorphic variants among infertile patients compared with fertile donors. The results suggest its impact on fertility.

Additional findings showed that female polymorphism carriers had a higher risk for embryo aneuploidy compared with females with a normal karyotype. Prior research has shown a higher incidence of chromosomal polymorphisms in infertile patients, but the relationship between infertility and these variants remains unclear.

“The application of a comprehensive chromosome screening to select euploid embryos could improve IVF success rates among chromosomal polymorphism carriers,” said study co-author Ruth Morales. “One may consider withdrawing donated oocytes with polymorphic variants from the donation program, and analyzing the rate of sperm aneuploidy in sperm donors carrying a polymorphism.”