New Data, New Directions: Bispecific Antibody Advances and CAR T-Cell Evidence in Relapsed/Refractory Multiple Myeloma
ByRyan Haumschild, PharmD, MS, MBA, CPEL ,Zahra Mahmoudjafari, PharmD, MBA, BCOP, FHOPA,Al-Ola Abdallah, MD,Anjulie Quick, MD Zahra Mahmoudjafari, PharmD, MBA, BCOP, FHOPA, highlights key bispecific antibody updates from ASCO and EHA, including updated data from the MajesTEC-6 trial evaluating elranatamab plus daratumumab and lenalidomide in newly diagnosed patients, and the MajesTEC-5 data demonstrating high response rates and minimal residual disease negativity with teclistamab-based induction in transplant-eligible patients, as well as a growing trend toward less frequent dosing schedules to reduce treatment burden and infection risk, and increasing real-world evidence supporting outpatient step-up dosing administration at both academic and community sites.