Videos

3 experts in this video

Panelists discuss how subcutaneous checkpoint inhibitors are appropriate for nearly all patients except those with severe cachexia limiting injection sites, with patient conversations emphasizing equivalent efficacy data, safety profiles, quality of life benefits including potential home administration, and the option to maintain IV therapy for patients who prefer their current regimen.

5 experts are featured in this series

Panelists discuss the long-term safety and durability of CDK4/6 inhibitors, highlighting data supporting sustained efficacy and manageable toxicity over years of treatment.

4 experts are featured in this series.

Panelists discuss how dose reductions for CDK4/6 inhibitors are commonly needed due to neutropenia, thrombocytopenia, diarrhea, and other toxicities but do not compromise efficacy based on subgroup analyses from major trials, while dose escalation strategies (particularly starting abemaciclib at 50 mg and gradually increasing) have been successfully implemented based on the TRADE study data to reduce early discontinuation rates by approximately 50%, though practical challenges exist with pharmacy dispensing and patient questions about why escalation to full dose is necessary when lower doses maintain efficacy.

3 experts in this video

Panelists discuss how subcutaneous administration enhances patient satisfaction by reducing venipuncture trauma and wait times, creates cost savings through eliminated IV supplies and shortened chair occupancy, enables higher infusion center throughput, and garners strong nursing support due to reduced patient distress during administration.

An expert discusses how improving shingles vaccination rates relies on patient education; effective use of technology like EHRs to identify eligible individuals; and persistent, multichannel communication by pharmacists to encourage vaccination and address barriers such as cost and awareness.

An expert discusses how low shingles vaccination rates stem from gaps in patient education, cost concerns, and access barriers, emphasizing that clear communication about vaccine efficacy, reduced out-of-pocket costs, and targeted outreach are key to increasing uptake, especially among older and rural populations.

3 experts in this video

Panelists discuss how implementing subcutaneous checkpoint inhibitors requires navigating temporary J-codes and reimbursement delays, considering economic impacts on institutional revenue streams, building indication-specific electronic treatment plans, and adopting provider-driven rather than mandated prescribing approaches while anticipating future dynamics including biosimilar competition and Inflation Reduction Act implications.

3 experts in this video

Panelists discuss how the MK-3475A-D77 trial demonstrated subcutaneous pembrolizumab’s pharmacokinetic comparability and equivalent efficacy to IV formulation in patients with metastatic non–small cell lung cancer receiving combination chemotherapy, with administration requiring approximately 2 minutes for 5 mL volume and showing comparable safety profiles.