
Before weighing new options, the panel resets the foundation: how antiretroviral classes work, what the 2026 DHHS update actually changed, and why therapy should start as soon as possible.

Before weighing new options, the panel resets the foundation: how antiretroviral classes work, what the 2026 DHHS update actually changed, and why therapy should start as soon as possible.

Integrase inhibitors remain the clear first choice, yet prior long-acting PrEP exposure and the practical realities of same-day starts are reshaping when alternatives make more sense.