CASE 1
KE is a 52-year-old woman who was admitted to the hospital after she was found to have splinter hemorrhages in her nailbed accompanied by generalized malaise for 2 weeks. She presented with a temperature of 102.1°F, a white blood cell count of 14.1 × 103 cells/mL, and a heart rate of 114 beats/min. Blood cultures were ordered and grew Enterococcus faecalis susceptible to gentamicin. A transesophageal echocardiogram revealed vegetation on the mitral valve, and KE was given a diagnosis of native valve endocarditis. The pharmacist receives an order for gentamicin 3 mg/kg IV once daily and ampicillin 2 g IV every 4 hours. KE’s creatinine clearance is 106 mL/min and she has no known drug allergies.”
Do you believe this is an appropriate antibiotic regimen for KE’s infective endocarditis caused by enterococci?

CASE 2
KS is a 28-year-old woman who presents to your community pharmacy with a prescription for podofilox 0.5% gel applied twice a day for 3 days, followed by 4 days of no therapy. KS was told by her doctor to repeat that regimen for up to 1 month or until clearance of her external anogenital warts. KS tells you she has used podofilox gel to treat her genital warts with limited success in the past. She attributes some of the past lack of effectiveness to unintentional nonadherence due to the complexity of the regimen.
As the pharmacist, what suggestions might you have for KS?