compounding HOTLINE

SEPTEMBER 01, 2007
Martin A. Erickson III, RPh

A physician wrote instructions for ?Glycolic acid facial lotion with Veegum.? Any suggestions?

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Glycolic Acid Facial Lotion
Calculated to Make 100 mL


Glycolic acid 70% solution1.500 mL
Magnesium aluminum silicate (Veegum)
5% colloidal dispersion5.000 mL
Methylparaben0.050 g
Propylparaben0.025 g
Ammonium hydroxide 28% solution qs to adjust pH
Purified water USP qs ad100.000 mL


  1. Prepare the magnesium aluminum silicate 5% colloidal suspension by dispersing 5 g of magnesium aluminum silicate in a small amount of water and stirring vigorously to obtain a smooth paste, then bringing to volume with purified water with stirring. When the dispersion is homogeneous, allow it to stand: it will form a smooth, creamy, thixotropic mixture.
  2. Dissolve the methylparaben and propylparaben in 94 mL of purified water. If necessary, heat to 70? to 75? C to facilitate dissolution.
  3. Allow mixture in (2) to cool.
  4. Add the glycolic acid to the mixture in (3). Add ammonium hydroxide 28% solution dropwise with stirring to obtain pH 4 to 4.5.
  5. Add the magnesium aluminum silicate 5% colloidal dispersion to (4) with stirring to homogeneity.
  6. Rinse the graduated cylinder used to measure the magnesium aluminum silicate colloidal dispersion with aliquots of the mixture in (5) into the bulk of the preparation.
  7. Bring the volume of mixture in (6) to volume with purified water, and stir to homogeneity.

Notes: No claims are made as to the uses, safety, efficacy, or bioavailability of this product. The formula is for informational purposes only.