Compounding HOTLINE

JUNE 01, 2006
Martin A. Erickson III, RPh

Q: I have an order for nifedipine 0.2% cream for anal fissures. Can you supply a formulation for this cream?

A: For topical local use, a poloxamer gel will provide a formulation that will remain in place at body temperature, because the gel exhibits inverse temperature/viscosity behavior. The material, after compounding, has the appearance of a vanishing cream.


  1. Calculate the required quantity of each ingredient.
  2. Accurately weigh/measure each ingredient.
  3. Levigate nifedipine with the ethoxy diglycol to make a smooth paste.
  4. Add the lecithin:isopropyl palmitate 50:50 solution. Mix thoroughly.
  5. Add sufficient Pluronic F-127 20% gel to desired total volume. Use mechanical shear force, to blend thoroughly (for example, syringe-to-syringe method or Unguator mixing device).
  6. Package and label.


No claims are made as to the uses, safety, efficacy, or bioavailability of this product. The formulas are for informational purposes only. .

Mr. Erickson is director of professional affairs at Gallipot Inc.

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