FDA Alert: Reduce Risks of Combined Use of Opioid Addiction Medications and CNS Depressants
September 21st 2017FDA officials have issued a drug safety communication advising that buprenorphine and methadone should not be withheld from patients taking benzodiazepines or other central nervous system (CNS) depressants.
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5-FU Toxicity and DPD: A New Option to Treat Pyrimidine Analogue Overdose
September 21st 20175-Fluorouracil is the mainstay of treatment for many cancers, with upwards of 30% rates of adverse effects. DPD deficiency can further amplify these effects and even lead to life-threatening toxicity. Uridine triacetate is FDA approved for 5-FU and capecitabine overdose treatment within 96 hours of administration.
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