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Ciltacabtagene autoleucel (cilta-cel) CAR T-cell therapy is currently being evaluated for the treatment of patients with relapsed and/or refractory multiple myeloma.

When the mRNA was removed, these remained in the cell for a long time and were able to maintain their function, new study results show.

Mathematical model from Penn State shows an alternative to business shutdowns and stay-at-home orders that are unsustainable over time.

Study does not show clinically significant improvements in overall survival but does show benefits in secondary endpoints, which included rates of distant metastases, deaths due to prostate cancer, and PSA failure.

Durvalumab (Imfinzi, AstraZeneca), combined with standard-of-care chemotherapy, demonstrated a clinically meaningful benefit in patients with advanced biliary tract cancer.

Study finds that 16.9% of stomach cancers, 11.9% of endometrial cancers, 11.0% of kidney cancers, 9.3% of colon cancers, 8.1% of esophageal cancers, 6.5% of female breast cancers, and 3.9% of urinary bladder cancers were associated with a low level of exercise.

Proposed demonstration project could have a negative effect on people with certain conditions, such as stroke, traumatic brain injury, and spinal cord injury.

Mark Garofoli, director of Experiential Learning Program at WVU School of Pharmacy, discusses his CPhT 2021 conference presentation regarding the role and impact of pharmacy technicians on opioids in the pharmacy.

These biomarkers may be able to control inflammation in the body once infected with COVID-19 and can help determine the seriousness of the infection, the researchers noted.

The study also found that certain E. coli cells in these microenvironments were able to survive phage treatment without acquiring genetic resistance.

Pembrolizumab (Keytruda) can be used for multiple cancer types, including melanoma, non-small cell lung cancer, and head and neck squamous cell cancer.

Asciminib (Scemblix) approved for patients with Philadelphia chromosome–positive chronic myeloid leukemia (CML) in chronic phase who were previously administered 2 or more tyrosine kinase inhibitors.

Pfizer and BioNTech have also announced that they will be providing the US government with an additional 50 million of the 10 μg doses, with an expected delivery by April 30, 2022.

The study was designed to evaluate elacestrant as a monotherapy compared to the standard of care for the treatment of estrogen receptor-positive/human epidermal growth factor receptor 2 advanced or metastatic breast cancer.

This developing technology offers opportunities for decentralized record-keeping and tracking of transactions, as well as increased overall efficiency and the removal of unnecessary intermediaries.

Mitigating the likelihood of pharmacy staff burnout requires a multifactorial approach.

The study sought to highlight the issues with the correct routing of discontinued medications, which increases the risk of medication safety events.

The analysis found that patients’ quality of life did not change significantly over time during treatment with immune checkpoint inhibitors.

Chemotherapy for colorectal cancer include 5-fluorouracil (5-FU), capecitabine (Xeloda), irinotecan (Camptosar), oxaliplatin (Eloxatin), and trifluridine and tipiracil (Lonsurf).

Precision dosing technology uses multiple patient-specific factors to individualize medication doses, helping clinicians reduce medication errors that lead to adverse events.

Those aged 18 to 34 years self-treat with cannabidiol or cannabis at 2 times the rate of people aged 45 years or older.

The phase 2 Elara trial for the follicular lymphoma treatment met its primary endpoints, Novartis says.

ARTISTRY-7 will analyze the anti-tumor activity and safety of the combination compared with chemotherapy for individuals with platinum-resistant ovarian cancer.

Investigators conclude that minimal residual disease cells, or those that survive the initial treatment, may carry some form of epigenetic and metabolic memory of the tumor.

Gyang and Hansen discussed any new or existing treatment options for patients, the role of the pharmacist changing, and what they wish others knew about MS.

The multi-institutional clinic trial also concluded that there was no negative impact to quality of life for these patients.

The investigators said that the trial data showed potentially clinically meaningful improvements in both progression-free survival and overall survival in pre-specified subgroups of patients based on the baseline inflammatory biomarker, hs-CRP, as well as other biomarker-defined subgroups.

Paula Durlofsky, PhD, a writer for the American Psychological Association's Device Management and Digital Intelligence committee discusses how social media has impacted the mental health of health care professionals in recent years, including the COVID-19 Pandemic.