CLINICAL ROLE -
Diuretics, ACEIs, ARBs, and NSAIDs: A Nephrotoxic Combination
This triple therapy can increase the risk of acute renal failure.
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Warfarin and Levothyroxine Revisited
A recent study offers encouraging new information on hemorrhage risk.
Stribild-A New Approach to Pharmacoenhancement
Pharmacoenhancers can help minimize costs and maximize effectiveness.
Rare But Serious Drug Interactions
In the case of severe but infrequent interactions, pharmacist awareness is key.
Why Can't We Just Get Relevant Alerts?
It is difficult to account for all the variables that factor into interactions.
Avoiding Lapatinib Interactions
Interactions with this tyrosine kinase inhibitor arise due to its pharmacokinetic characteristics.
Enzyme Inducer Plus Enzyme Inhibitor: What Will Happen?
When evidence is lacking for a specific interaction, an analysis of the underlying mechanism is warranted.
Goldenseal Drug Interactions
Clinically significant drug interactions for goldenseal provide evidence for cautious use of this popular herbal product.
Metoclopramide and Dyskinesia
Movement-related adverse events are not uncommon in patients taking metoclopramide.
Yohimbine: Old Drug With New Interactions
Yohimbine is available by prescription or in herbal supplements and its interactions include inhibiting the effects of antihypertensives.
Genetics and Enzyme Inhibitor Interactions
The extent to which patients metabolize enzymes can have a big impact on the effectiveness of their pharmacologic therapy.
Methotrexate and Proton Pump Inhibitors
Patients taking methotrexate who also take certain medications for gastric problems must time their dosage carefully.
Do Antidepressants Increase Warfarin Bleeding Risk?
Rivaroxaban: A New Oral Anticoagulant
As more patients begin medication regimens that include rivaroxaban, pharmacists should be aware of its known interactions.
Oral Contraceptives and Reduced Lamotrigine Efficacy
In this unusual interaction, oral contraceptives act as the precipitant rather than the object drug.
Get to Know an Enzyme: CYP2C8
Pharmacists should be familiar with drugs that impact the activity of the enzyme cytochrome P450 2C8.
Prophylactic Dose Adjustments in Management of Drug Interactions
Adjusting a drug's dosage to prevent an anticipated interaction is a tactic fraught with potential dangers.
Drug Interactions with Simvastatin: The Risk Continues
Recent FDA actions regarding simvastatin mean that pharmacists should refresh their knowledge of this cholesterol-lowering medication.
The Highway Metaphor Myth
Customization of Drug Interaction Software: Caution is Warranted
Controversial Drug Interactions
When contradictory data are presented regarding a drug interaction, pharmacists should weigh the evidence ad make their own decisions.
CCBs and CYP3A4 Inhibitors: Watch Out for Enhanced Cardiovascular Response
Bradycardia Due to Rivastigmine Drug Interactions
Rivastigmine is a cholinesterase inhibitor that can interact with other drugs to cause potentially dangerous cardiovascular side effects.
Time Course for Enzyme Induction and Deinduction
Pharmacists must consider the potentially prolonged onset and offset of drug interactions when enzyme induction or deinduction is involved.
Does the Truth Wear Off?
Initial research findings sometimes diminish over time. Does this phenomenon apply to drug interactions?
Trimethoprim and Potassium-Sparing Drugs: A Risk for Hyperkalemia
Pharmacists should closely monitor patients who take trimethoprim and other drugs that increase serum potassium.
Triple Drug Interactions
Although triple drug interactions are not well studied, available information points to some general principles that may be useful in managing such combination.
Dabigatran: A New Oral Anticoagulant
Patients taking dabigatran etexilate should be closely monitored for altered responses to this newly approved oral anticoagulant.
Effect of Gender on Drug Interactions: Metoprolol- Diphenhydramine
A recent study revealed gender differences in the severity of interactions between metoprolol and diphenhydramine.
When Is an Interaction Likely to Cause Harm?
Simple calculations can be used to help pharmacists evaluate a drug interaction and its potential to cause significant harm.