Valproic Acid and Carbapenem Antibiotics InteractionOctober 18th 2018
The combined use of valproic acid and a carbapenem is likely to occur in patients with central nervous system infections resulting from head trauma or surgical procedures; serious systemic infections, including pneumonia; and generalized seizure disorders.
Linezolid and Serotonin SyndromeSeptember 23rd 2018
The antibacterial agent linezolid is a nonselective inhibitor of monoamine oxidase (MAO), and when it is combined with serotonergic agents, it has been associated with serotonin syndrome. A recent case of serotonin syndrome was reported with concur- rent use of linezolid and methadone.
Endothelin Receptor Antagonist Drug InteractionsJune 13th 2018
Endothelin antagonists—ambrisentan (Letairis), bosentan (Tracleer), and macitentan (Opsumit)—are indicated to treat pulmonary arterial hypertension. Although these drugs have similar pharmacologic activity, they differ in their potential for their plasma concentrations to be altered by other medications.