CLINICAL ROLE -
Trimethoprim and Potassium-Sparing Drugs: A Risk for Hyperkalemia
Pharmacists should closely monitor patients who take trimethoprim and other drugs that increase serum potassium.
Read More
Triple Drug Interactions
Although triple drug interactions are not well studied, available information points to some general principles that may be useful in managing such combination.
Dabigatran: A New Oral Anticoagulant
Patients taking dabigatran etexilate should be closely monitored for altered responses to this newly approved oral anticoagulant.
Effect of Gender on Drug Interactions: Metoprolol- Diphenhydramine
A recent study revealed gender differences in the severity of interactions between metoprolol and diphenhydramine.
When Is an Interaction Likely to Cause Harm?
Simple calculations can be used to help pharmacists evaluate a drug interaction and its potential to cause significant harm.
Should We Remove the Traffic Lights?
How to Address a Drug Interaction Alert
When faced with drug interaction alert, pharmacists should assess the level of risk and have a standardized action plan in place for staff members to follow.
Drug Interactions: Combining NSAIDs and Bisphosphonates
Because many patients who take bisphosphonates also take nonsteroidal anti-inflammatory drugs for other conditions, it is important to determine if their combination will have a negative effect.
Drug Interactions: Cranberry Juice and Warfarin: What Have We Learned?
New case reports and clinical trials are examined that provide additional evidence on the interaction between cranberry juice and warfarin.
Drug Interactions: Does Menthol Affect Warfarin Response?
Some debate exists surrounding the use of menthol cough drops in patients on warfarin because of altered international normalized ratio levels-is there enough evidence to prove a direct correlation?
Drug Interactions with Tyrosine Kinase Inhibitors
Tyrosine kinase inhibitors (TKIs) are indicated for the treatment of a variety of malignancies due to their ability to interfere with cell communication and growth. Interactions that affect TKI metabolism are discussed.
Drug Interactions: Absence of Proof Is Not Proof of Absence
The debate surrounding whether an interaction occurs between oral contraceptives and antibiotics continues. It the use of antibiotics with oral contraceptives likely to result in an unintended pregnancy?
Drug Interactions: Clopidogrel-Proton Pump Inhibitor Interaction: An Update
This column is an update to the April 2008 column that discussed the possible interaction between clopidogrel and proton pump inhibitors-new studies and data are brought into perspective.
Drug Interactions: Safely Using Quetiapine
Quetiapine, an atypical antipsychotic, has become one of the most widely prescribed psychiatric medications in the United States; several reminders are presented here to ensure safe use of the drug.
Drug Interactions: Drug Interactions with St. John's Wort
Our Columnists provide an update on the many drug interactions associated with the commonly used herbal supplement, St. John's Wort.
Ignoring Drug Interactions for the Right Reasons
The Effect of Hepatic Disease on Drug Interactions
New Oxycodone Drug Interactions
Drug Interactions: Interactions Involving Drugs That Prolong the QTc Interval
Tramadol and Serotonin Syndrome
More Evidence of a Warfarin-Antibiotic Interaction
The Dangers of Beta-Blockers and Epinephrine
Drug Interactions: Oatmeal: Good for Your Heart or Maybe Not?
Oatmeal is commonly touted as a healthy, cholesterol-lowering food—but does it present an interaction risk with digoxin?
Drug Interactions: Beware of CYP2D6 Inhibitors in Patients Taking Tamoxifen
Being aware of drugs that inhibit CYP2D6 is especially important for patients taking tamoxifen.
Drug Transporters: The Final Frontier for Drug Interactions—Part 2
The second in a pair of articles on drug transporters, this article focuses on uptake transporters that actively pump drugs into cells.
Drug Interactions: Interaction Decisions: Using Evidence to Weigh Risks
Reducing the risk of adverse drug interactions requires taking various items into consideration, including possible outcomes.
Therapeutic Benefits of PPIs
Drug Transporters: The Final Frontier for Drug Interactions
Transporter proteins transport drugs in and out of cells and are susceptible to reduced or enhanced activity depending on drug exposure.
Drugs That Inhibit Levothyroxine Absorption
Protease Inhibitors and PPIs
Proton pump inhibitors are potent inhibitors of gastric acid secretion; their interactions with protease inhibitors are discussed here.