Rucaparib May Potentially Benefit Patients with Advanced Pancreatic Cancer
Rucaparib, an (ADP-ribose) polymerase (PARP) inhibitor approved for the treatment of ovarian cancer, may have potential clinical benefit for patients with advanced pancreatic cancer and a BRCA1/2 mutation.
Rucaparib, an (ADP-ribose) polymerase (PARP) inhibitor approved for the treatment of ovarian cancer
may have potential clinical benefit for patients with advanced pancreatic cancer and a BRCA1/2
mutation, according to findings from a phase 2 trial.
With a poor prognosis and limited treatment options, pancreatic cancer is projected to become the second leading cause of cancer death by 2020. Approximately 9% of pancreatic cancers have a BRCA1 or BRCA2
mutation. As studies of BRCA1/2
mutations in breast and ovarian cancer have shown clinical benefit with PARP inhibitors, researchers sought to determine the clinical benefit in patients with pancreatic cancer.
The global, phase 2 study enrolled 19 patients aged 18 and older with locally advanced or metastatic pancreatic cancer with a known BRCA1/2
mutation between April 2014 and April 2016. Patients could have received up to 2 prior lines of chemotherapy but could not have received prior therapy with a PARP inhibitor.
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