Daily Medication Pearl: Azithromycin Ophthalmic Solution (AzaSite)
AzaSite is indicated for the treatment of bacterial conjunctivitis caused by CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumoniae.
Medication Pearl of the Day: Azithromycin Ophthalmic Solution (AzaSite)
Indication: AzaSite is a macrolide antibiotic indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following microorganisms: CDC coryneform group G, Haemophilus influenzae, Staphylococcus aureus, Streptococcus mitis group, and Streptococcus pneumoniae.
Insight:
- Dosing: Instill 1 drop in the affected eye(s) twice daily, 8 to 12 hours apart for the first 2 days and then instill 1 drop in the affected eye(s) once daily for the next 5 days.
- Dosage forms: 5 mL size bottle filled with 2.5 mL of 1% sterile topical ophthalmic solution.
- Adverse events (AEs): The most common AE reported in patients was eye irritation (1%-2% of patients).
- Mechanism of action: Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interfering with microbial protein synthesis.
- Manufacturer: Inspire Pharmaceuticals
Sources:
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