Daily Medication Pearl: Armodafinil (Nuvigil)


Armodafinil and modafinil have wake-promoting actions similar to sympathomimetic agents.

Medication Pearl of the Day: Armodafinil (Nuvigil)

Indication: Armodafinil is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD).


  • Dosing: OSA or narcolepsy 150 mg to 250 mg once a day in the morning.
  • Dosage forms: Tablets 50 mg, 150 mg, 200 mg, and 250 mg.
  • Adverse events: Most common adverse reactions (³5%) are headache, nausea, dizziness, and insomnia.
  • Mechanism of action: Armodafinil and modafinil have wake-promoting actions similar to sympathomimetic agents, including amphetamine and methylphenidate, although their pharmacologic profile is not identical to that of the sympathomimetic amines.
  • Manufacturer: Teva Pharma


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