Medication Pearl of the Day: Aducanumab-avwa (Aduhelm)
Indication: Aducanumab-avwa is an amyloid beta-directed antibody indicated for the treatment of Alzheimer disease.
- Dosing: The recommended maintenance dosage is 10 mg/kg administered as an intravenous infusion over approximately 1 hour every 4 weeks.
- Dosage form: 170 mg/1.7 mL (100 mg/mL) solution in a single-dose vial and 300 mg/3 mL (100 mg/mL) solution in a single-dose vial.
- Adverse events (AEs): Most common AEs (at least 10% and higher incidence compared to placebo): ARIA-Edema, headache, ARIA-H microhemorrhage, ARIA-H superficial siderosis, and fall.
- Mechanism of action: Aducanumab-avwa is a human, immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta.
- Manufacturer: Biogen