Cost-Benefit Considerations for CAR T Cell Therapy


CAR T-cell therapies tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta) have been scrutinized for their high costs.

Both FDA-approved chimeric antigen receptor (CAR) T-cell therapies, tisagenlecleucel (Kymriah, Novartis) and axicabtagene ciloleucel (Yescarta, Kite Pharma/Gilead), may come with hefty price tags, but the therapies are priced in alignment with their clinical value, according to an Institute for Clinical and Economic Review (ICER) report.

In August, tisagenlecleucel gained approval for the treatment of B-cell acute lymphoblastic leukemia (B-ALL) in certain pediatric and young adult patients. In October, axicabtagene ciloleucel was green lit by the FDA for the treatment of adult patients with diffuse large B-cell lymphoma who have not responded to or have relapsed after 2 other kinds of treatment; tisagenlecleucel is currently under FDA evaluation for this indication.

Using a cohort of patients aged 0 to 25 with relapsed/refractory B-ALL and a cohort of patients aged 18 and older with relapsed/refractory B-cell lymphoma who were ineligible for auto-stem cell transplant, the report compared the CAR T therapies with chemotherapy. The average sales price for chemotherapy treatments were used, while the wholesale acquisition cost was used for CAR T therapies, as it was the only available estimate. For this indication, the cost of tisagenlecleucel is $475,000, and the cost of axicabtagene ciloleucel is $373,000, not including other costs related to the administration of CAR T therapy. A hospital mark-up was added for each hospital-administered treatment. It was assumed that the survival benefits demonstrated over the short duration of clinical trials would persist over a patient's lifetime.

For more information, please visit

Related Videos
Pride flags during pride event -- Image credit: ink drop |
Video 14 - "Closing Remarks on RSV Vaccinations"
Video 13 - "Understanding RSV Infection Patterns and Seasonal Outbreaks"
A panel of 4 experts on breast cancer
A panel of 4 experts on breast cancer
Female Pharmacist Holding Tablet PC - Image credit: Tyler Olson |
pain management palliative care/Image Credits: © Aleksej -
African American male pharmacist using digital tablet during inventory in pharmacy - Image credit: sofiko14 |
palliative and hospice care/ Image Credits: © David Pereiras -
© 2024 MJH Life Sciences

All rights reserved.