Association Between Pregnancy Losses and Type 2 Diabetes Risk

Study shows a significant and consistent association between pregnancy loss and type 2 diabetes, which increased with more losses.

More pregnancy losses for women could lead to a higher risk of developing type 2 diabetes, new research findings showed.

Pia Egerup, MD, and a team of Denmark-based investigators used a Danish nationwide data cohort of women born from 1957-1997. They found a significant and consistent association between pregnancy loss and later type 2 diabetes increased with more losses.

The investigators identified all women born from 1957-1977 with a diagnosis of type 2 diabetes during 1977-2017. Every woman with diabetes (case population) was matched by birth year and educational level to 10 control women without diabetes in the general Danish population.

A diagnosis of type 2 diabetes was defined based on an algorithm for chronic diseases published by The Danish Health Data Authority. Age at diagnosis was determined as the first hospital contact with a discharge diagnosis or a first filled prescription of glucose-lowering drugs.

The team calculated the odds of developing type 2 diabetes with different numbers of pregnancy losses. Each pregnancy loss was categorized as the total number of pregnancy losses before the index date: 0, 1, 2, or >3 losses. The investigators further divided the women with 0 pregnancy losses into those who achieved a pregnancy (live birth, stillbirth, molar pregnancy, ectopic pregnancy, or induced abortion) and those who never achieved a pregnancy.

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