Race Should Not Determine Drug Therapy

Pharmacy Times, Volume 0, 0

When deciding the appropriate course of treatment for high blood pressure, raceshould not be a major criterion for selecting a therapy, according to a study reported inHypertension (June 2004). Using data collected during a clinical trial of 1 type of bloodpressure lowering drug?the angiotensin-converting enzyme inhibitor quinapril?theresearchers determined the influence of race on blood pressure response.

Although blood pressure lowering with quinapril treatment was, on average,greater for Caucasians than African Americans, the response varied for both groups,and the range overlapped substantially. The researchers noted that age, obesity,and gender accounted for a majority of racial differences in response to the quinapriltreatment. "The results of these analyses highlight the potential pitfalls of comparingblood pressure responses between race groups without adequate adjustment for arange of potential confounding variables," concluded the researchers.