CLINICAL ROLE -
“If It Can't Kill, It’s Not Effective.” How Understanding T-cell Exhaustion Can Improve CAR T-cell Therapy
CAR T cells may have the ability to be engineered and remain consistently functional, leading to more effective cancer treatment.
Understanding the Role of Mononuclear Phagocytes in the Tumor Microenvironment
A researcher suggests that understanding specific cell function in the tumor microenvironment can help create effective and individualized immunotherapy cancer treatments.
Researchers Are Developing Bispecific CAR Proteins to “Wake Up” the Immune Systems of Cancer Patients
Yvonne Chen, PhD, discusses some of the strategies that researchers are using to improve T-cell effectiveness and overcome immunosuppression in CAR T-cell therapy.
An Integrative Efficacy Score May Be Effective to Evaluate Drug Benefit in Oncology
An integrative efficacy score would incorporate the depth, duration, and prevalence of tumor response.
Peptide-Based Cancer Vaccines May Offer Effective Protection Against Aggressive Tumors
New research in immunotherapy is exploring vaccines to treat cancer, whether preventative or reactive against current tumors.
Tertiary Lymphoid Structure May Improve Immunity for Patients With Ovarian Cancer
A researcher discusses how developing tertiary lymphoid structures may reach a greater maturity level within the tumor microenvironment.
Addition of Anti-TIM-3 Monoclonal Antibody Could Enhance Effects of Paclitaxel, Docetaxel
Given that dendritic cells are necessary for anti-tumor response, researchers investigated which pathways stop these cells from performing their full functions.
Researchers Explore More Safe and Effective CAR T-Cell Therapy for Cancer Treatment
Yvonne Chen, PhD, discusses her research to engineer more safe and effective next-generation CAR-T therapy for cancer immunotherapy.
Researchers Explore Approaches to Block T-Cell Exhaustion
Expert discusses whether epigenetic programs regulate human T cell exhaustion and whether epigenetic-based strategies can be used to enhance T cell-based therapies.
Researchers Tackle Limitations, Opportunities of CAR T Cells in Solid Tumors
New research has shown significant promise for the use of CAR T-cell therapies in solid tumors.
