Glycosite-specific antibody‒drug conjugates (gsADCs), harnessing Asn297 N-glycan of IgG Fc as the conjugation site for drug payloads, usually require multi-step glycoengineering with 2 or more enzymes, which limits the substrate diversification and complicates the preparation process.
PrEP therapy has revolutionized HIV treatment by protecting patients who are high risk for acquiring the virus.
The role of the pharmacist in sickle cell disease management revolves around appropriate pain management.
The study has met its primary endpoint, with approximately 78.4% of women who continued taking the drug achieving the sustained responder rate through week 76.
Anna Pham, PharmD, PGY2 ambulatory care resident at Intermountain Healthcare, discusses the role of ambulatory care pharmacists in primary care clinics.
Since the COVID-19 pandemic began, more than 10.6 million children have tested positive for the virus in the United States.
The drug is being evaluated as the first potential allogeneic advanced cell therapy donor source for patients with blood cancers in need of a transplant.
Utilization of the RAPID3 tool can be a beneficial way for pharmacists to complete disease activity assessments without physically seeing the patient in a clinic setting.
Selpercatinib (Retevmo, Loxo Oncology) is FDA-approved to treat 3 types of tumors—metastatic RET fusion-positive non-small cell lung cancer, advanced medullary thyroid cancer (MTC) or MTC that has spread, and advanced RET fusion-positive thyroid cancer.
Buprenorphine (Butrans) is a partial opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment for which alternative treatment options are inadequate.
Aimee Banks, PharmD, BCPS, MSCS, clinical pharmacist in the Multiple Sclerosis Clinic at Vanderbilt University Medical Center, discusses the role of the pharmacists in patient care, improving outcomes, and managing transitions of care.
Paxlovid treats COVID-19 in adults who do not require supplemental oxygen and who are at an increased risk of progression to severe disease.
Expanded glomerular filtration rate (GFR) testing in the United States could be one step toward minimizing disparities in renal formulas, Beumer said.
There are more than 70 cases of monkeypox across 18 states in the United States, as of this week.
Pembrolizumab is an anti-PD-1 therapy that works by increasing the ability of the immune system to detect and fight tumor cells.
Although the COVID-19 pandemic saw the rapid hemorrhaging of women from careers in science and medicine, research shows the toxicity experienced by women may be structural in nature.
Trial court denial of claim Is pursued on appeal based on alleged error by judge when granting summary judgment.
Unlike the 2022 simplification updates for the hepatitis B and pneumococcal vaccine recommendations, ACIP’s recommendations for patient eligibility for zoster vaccination have become more complicated this year.
The Advisory Committee on Immunization Practices and CDC have prioritized making HBV vaccination recommendations simpler to ease the vaccination process for immunizers and to decrease barriers.
Current development efforts in IVIG are focused on new routes of administration for immunoglobulin that can overcome the limitations of intramuscular administration.
Fentanyl citrate (Actiq) is an opioid agonist indicated for the management of breakthrough pain in cancer patients.
Data from the phase 2/3 TeenCOVE trial in adolescents met the primary immunogenicity endpoint.
The step-up dosing approach with glofitamab in a phase 1 trial enabled researchers to minimize cytokine release syndrome while maximizing outcomes.
Many health care systems are turning to biosimilars to provide clinical outcomes that are similar to those provided by reference products, but at a reduced cost.
Jeff Betcher, BSPharm, MBA, director of pharmacy at Mayo Clinic in Arizona, discusses how automated chemotherapy dose rounding can help decrease drug waste and cost.
As best practices are established throughout the specialty pharmacy’s entire network, better patient outcomes become possible.
Expert notes that any unease around the use of radiopharmaceuticals is just due to a lack of familiarity with the field.
Training pharmacy technicians to evaluate tasks such as appropriate site of care and plan benefits can reduce the workload for the pharmacist.
Tina Saleh, PharmD, PGY1 specialty pharmacy resident at the University of Illinois Hospital and Health Science System, discusses how oral anticancer agents differ from infusions and how pharmacists can improve tolerability for patients.
Certain areas of chapters written by US Pharmacopeia have evolved since being made official and have become standard best practices today.
