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Camizestrant is a next-generation oral SERD and pure Erα antagonist that has demonstrated anti-cancer activity across a range of preclinical models, including in patients with ER-activating mutations.

Inflammation-based prognostic scores can be a valuable tool in assessing the overall survival of patients with intrahepatic cholangiocarcinoma.

Otilimab also inhibits the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor.

The estimation of glomerular filtration rate based on cystatin C could provide a more robust prediction of cardiovascular disease and mortality in patients.

Covis announced positive topline results for 2 new medications that can treat patients with moderate to severe stable chronic obstructive pulmonary disease.

In a panel, pharmacy technicians discuss the future of pharmacy technicians in United States, Portugal, and the United Kingdom.

Results demonstrate improved progression-free survival in the overall patient population and in a prespecified biomarker subgroup of tumors with alterations in specific genes, AstraZeneca says.

Findings are encouraging for individuals with cancer who are receiving immune checkpoint inhibition treatment and want to get a third vaccine dose, investigators said.

Modifications related to final product verifications, immunizations, and remote work loom on the horizon for 2023.

Ozanimod is an oral, sphinogosine 1-phosphate (S1P) receptor modulator that binds with high affinity to S1P receptors 1 and 5.

By 2019, lung cancer mortality rates decreased by 5.4% in males since 2015, while deaths from ovary cancer have also declined rapidly over the past 2 decades.

In a panel, pharmacy technicians across the world discuss the role of automation in United States, Portugal, and the United Kingdom.

Although clinicians cited lack of time as a reason for not using patient-reported outcomes, patients with HIV viewed their use very positively.

Phase 2 APPLY-PNH trial shows positive results superiority vs anti-C5 treatment in adult patients with PNH with residual anemia despite prior therapy.

ASCP 2022 session presenters review the evidence that tipped the scales against the use of aspirin for primary prevention in patients aged 60 years or older.

The indication is approved under accelerated approval based on response rate, and continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

Research suggests that positron emission tomography scans are effective at detecting early and late Hodgkin’s lymphoma, and the results could help manage and reduce toxicity from current chemotherapies.

Understanding the novel mechanisms of multiple myeloma can help to develop better next-generation therapies that overcome drug resistance.

Study results indicate durable immune response from bivalent booster after 3 months of follow-up.

Highest prevalence is seen among adults, outpatients, and women and can cause persistent severe anosmia or hyposmia, findings indicate.

In a panel, pharmacy technicians across the world discuss what immunizations and point-of-care testing looks like in United States, Portugal, and the United Kingdom.

In a multivariable analysis, treatment with carboplatin is favored for extensive-stage cell lung cancer, even if it is not found to increase overall survival compared to standard care.

These study findings may have implications for monitoring for the development of ICANS in patients receiving CAR T-cell therapies for cancer, according to the authors.

Food insecurity has previously been linked to adverse cardiovascular outcomes, but research is limited regarding the local food environment and the association with death from heart failure.

The objective of the trial was to compare letermovir with valganciclovir in preventing CMV disease in adults who received a kidney transplant and who are at high risk for CMV disease.

ASCP 2022 session presenters discuss medications that can cause QTc prolongation, with a particular emphasis on a review of the literature with regards to QTc prolongation and antipsychotics.

In patients with hypoxic-ischemic brain injury, researchers observed no significant difference between liberal and restrictive oxygenation on any-cause death.

The Moderna mRNA-1273 vaccine was found to be effective for more than 50% of children aged 6 to 23 months.

SGLT-2 inhibitors, GLP-1 receptor agonists, and a non-steroidal mineralocorticoid receptor are all showing promise in the prevention and management of diabetic kidney disease.

News research results in Zambia also find that early intervention in the form of antiretroviral therapies and better nutrition may help close the gap.