Skylar Kenney, Assistant Editor

The investigators said these results suggest patients with low sTK1 activity levels have slow-growing disease, which can be initially controlled through single-drug endocrine therapy.

Robert Z. Orlowski, MD, PhD, director of the Myeloma Section at the University of Texas MD Anderson Cancer Center, reviewed novel agents in the treatment of triple-class refractory myeloma during a session at the 2021 annual meeting of the Society of Hematologic Oncology (SOHO).

By deactivating a component of the MAPK signaling pathway, researchers were able to reduce the proportion of leukemia cells in blood and bone marrow.

Treatment with neoadjuvant cisplatin and pemetrexed plus atezolizumab for pleural mesothelioma found to be safe in trial.

Cisplatin is frequently an effective therapy for pediatric cancer, but it is also known to cause permanent hearing loss in some patients.

Apalutamide (Erleada, Johnson & Johnson) demonstrated a strong prostate-specific antigen response and high adherence rates in patients with non-metastatic castration-resistant prostate cancer.

Funded by a grant from the National Institutes of Health, this trial is intended to test the safety and efficacy of a vaccine designed to selectively prevent the euphoric and toxic effects of oxycodone.

The investigators noted that heart attacks are often caused by the rupturing of vulnerable plaques, defined as plaques with a large lipid core with a thin fibrous cap that serves as a wall or barrier around the plaque to keep it intact.

The findings, published in the Journal of the American Heart Association, add to a list of cardiac risks experienced by patients with HIV.

Study suggests potentially expanding the use of immunotherapies in the elderly, a population in whom these therapies may be under-prescribed.

The investigators said that even patients with asthma showed no statistically significant deterioration in lung function, although there was a trend toward slightly lower measurements for the amount of air they could exhale forcibly in 1 second.

Bleeding in the upper GI tract is among the most common bleeding complications following acute myocardial infarction, causing considerable suffering and increasing the risk of death.

Diabetic kidney disease develops in nearly 40% of patients with diabetes and serves as the leading cause of chronic kidney disease worldwide, according to the study.

COVID-19 convalescent plasma administered within the first week of symptoms did not prevent disease progression in a high-risk group of outpatients.

A greater proportion of atogepant-treated participants achieved at least a 50% reduction in mean monthly migraine days.

Study suggests that lack of sleep in the first 6 months following childbirth can add between 3 and 7 years to the mother’s biological age.

The study authors note that they cannot conclude that there is a causal relationship between the COVID-19 vaccines and any of the individual incidents of Bell palsy reviewed.

Inspiratory muscle training was originally devised to be used by athletes and individuals with breathing problems such as chronic obstructive pulmonary disease, asthma, and bronchitis.

Individuals with COVID-19 were more likely to be asymptomatic if they contracted the virus from a primary case that was also asymptomatic.

Peptides that cause migraine pain can influence insulin production in mice, possibly by regulating the amount of secreted insulin or by increasing the number of pancreatic cells that produce it.

The investigators, from Washington University School of Medicine in St. Louis, note that the responses measured were one-third as strong as those mounted by healthy individuals.

It is currently debated whether or not sluggish cognitive tempo—defined as a collection of symptoms that include persistent dreaminess, fatigue, and slow working speed—is part of ADHD or separate from it.

Investigators from Oregon Health and Science University (OHSU) said that it is crucial to emphasize the importance of vaccinations, as well as the maintenance of public health measures that cut off the spread of the virus.

Study findings could influence how drug developers consider how opioid drugs cause tolerance and respiratory depression, and it suggests an alternative approach to developing safer analgesics.

OSA is associated with cardiovascular disease in adults, but less is known about how the condition affects the immediate and long-term heart health of children and adolescents.

Previous studies have demonstrated an association between low levels of vitamin D in the blood and pain, sensitivity to infection, fatigue, depression, and lower self-rated quality of life.

The mutated genes in question, TET2 and DNMT3A, each influence the efficacy of treatment in different ways.

Cities were ranked on a 50 point scale, weighing factors including therapy session rate by state, total prescription charges by state, their grade for mandatory treatment laws by state, criminalization of mental illness by state, number of residents per 1 mental health provider by county, poor mental health days by county, and overall community wellbeing.

The treatment was also well-tolerated, with a similar safety profile to placebo, according to the investigators.

Johnson & Johnson previously reported interim results from a phase 1/2a trial demonstrating the antibody responses generated by their vaccine were strong and stable through 8 months following immunization, published in the New England Journal of Medicine.