Skylar Kenney, Assistant Editor

Solutions could save federal government more than $1 billion annually for these single-source drugs.

Olumiant shows favorable long-term safety profile in rheumatoid arthritis.

Receipt of PrEP education or prescription relies heavily on a provider’s discretion, which can be subject to social biases.

Practicing mindfulness was associated with fewer psychological symptoms, such as posttraumatic stress, depression, and anxiety.

The panel also recommends considering risk factors for poor response, including uncontrolled disease, immunoparesis, the number of previous lines of therapy, and patient age.

This weight loss can prevent the onset of type 2 diabetes for new mothers.

Investigators have identified a novel signaling pathway and enzyme that may further the understanding of blood clot formation in patients with chronic kidney disease.

The trial randomized patients to receive TV-46000 once monthly, TV-46000 once every 2 months, or placebo, and found that patients had improved outcomes on TV-46000 regardless of dosing schedule.

It was previously known that beta-lactam antibiotics function by restricting cell wall growth, but the exact mechanics have remained unknown until now.

Patients were randomized 1:1 to receive either erenumab or topiramate, with the erenumab arm split into dosages of 70 mg or 140 mg.

The results were presented at the American Society of Nephrology Kidney Week 2021.

The phase 3 clinical trials evaluated the efficacy and safety of cariprazine as an adjunctive treatment for these patients.

No new safety concerns were encountered, which the investigators said support the frontline use of daratumumab plus lenalidomide and dexamethasone for patients with multiple myeloma who are ineligible for transplantation.

Study addresses the impact of COVID-19 on the mental health of older people.

Parents or legal guardians of children in this age range are now able to schedule appointments for vaccination.

A single 1200 mg subcutaneous dose of casirivimab and imdevimab (Regen-COV, Regeneron Pharmaceuticals), a preventative COVID-19 treatment, reduced the risk of contracting COVID-19 by 81.6% during months 2-8, according to additional results from a phase 3 trial published in The New England Journal of Medicine.

However, the trial failed to demonstrate that dose-escalated radiation therapy (RT) was superior to conventional RT.

The investigators found that older adults who studied Spanish had similar improvements to critical cognitive skills as those engaged in brain training activities specifically targeting those skills.

SER-109, an investigational, oral, biologically-sourced microbiome therapeutic designed to reduce recurrence of C. difficile infection (CDI), demonstrated a 31.1% absolute reduction in the rate of CDI recurrence over 12 weeks compared to placebo

Experts address cases for and against the use of surgical resection in the treatment of patients with neuroendocrine tumors and liver metastases.

The investigators caution that the quality of the evidence is variable and an optimal formulation or dose remains unknown.

The study also collected patient-reported outcomes in routine clinical practice to understand the impact of treatment on health-related quality of life.

TNBC is the most aggressive and lethal form of the disease.

Tralokinumab is a high-affinity human monoclonal antibody that binds to and inhibits interleukin-13, a key driver of atopic dermatitis symptoms.

Study does not show clinically significant improvements in overall survival but does show benefits in secondary endpoints, which included rates of distant metastases, deaths due to prostate cancer, and PSA failure.

Durvalumab (Imfinzi, AstraZeneca), combined with standard-of-care chemotherapy, demonstrated a clinically meaningful benefit in patients with advanced biliary tract cancer.

Prurigo nodularis has one of the highest quality of life impacts of any inflammatory skin disease with intense, chronic itch.

Study finds that 16.9% of stomach cancers, 11.9% of endometrial cancers, 11.0% of kidney cancers, 9.3% of colon cancers, 8.1% of esophageal cancers, 6.5% of female breast cancers, and 3.9% of urinary bladder cancers were associated with a low level of exercise.

Proposed demonstration project could have a negative effect on people with certain conditions, such as stroke, traumatic brain injury, and spinal cord injury.