CLINICAL ROLE -
Dolutegravir Is Susceptible to Chelation-Type Interactions
Common medications containing polyvalent cations should be separated to prevent decreased absorption of the HIV therapy.
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Watch for Interactions With Warfarin
Patients on this therapy should monitor their INR frequently, especially when adding other medications.
Keep an Eye on Protein Kinase Inhibitors
Medications in this drug class can alter the safety and efficacy of co-administered medications.