Safety Profile Associated with Dato-DXd

Pharmacists play a critical role in educating patients about potential side effects, monitoring for early signs of toxicity, and coordinating supportive care measures, including growth factor support for hematologic events. Awareness of these risks allows for proactive management, helps maintain treatment adherence, and optimizes patient outcomes while minimizing serious complications. Despite longer treatment durations with datopotamab deruxtecan (Dato-DXd), high-grade toxicities were comparable to other therapies, and treatment discontinuations due to adverse events were lower.