Medication Pearl of the Day: Exenatide (Bydureon)


Medication Pearl of the Day: Exenatide (Bydureon)

Indication: Exenatide (Bydureon) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings.


  • Dosing: Administer 2 mg by subcutaneous injection once every 7 days, at any time of day, with or without meals. Administer immediately after the powder is suspended.
  • Dosage forms: Bydureon is 2 mg exenatide for extended-release injectable suspension.
  • Adverse events (AEs): Most common (≥5%) AEs occurring more frequently than comparators in clinical trials were nausea, diarrhea, headache, vomiting, constipation, injection site pruritus, injection site nodule, and dyspepsia.
  • Mechanism of action: Incretins, such as GLP-1, enhance glucose-dependent insulin secretion and exhibit other antihyperglycemic actions following their release into the circulation from the gut. Bydureon is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying.
  • Manufacturer: Amylin Pharmaceuticals


Related Videos
cropped view of man performing chest compression on dummy during cpr training class - Image credit: LIGHTFIELD STUDIOS |
Medicine law concept. Judges gavel with pills | Image Credit: Iren Moroz -
Image credit: New Africa |
biosimilar word or concept represented by wooden letter tiles on a wooden table with glasses and a book | Image Credit: lexiconimages -
Image credit: alicja neumiler |
Laboratory test tubes and solution with stethoscope background | Image Credit: Shutter2U -
Image Credit: Pixel-Shot |
Pharmacist holding medicine box and capsule pack in pharmacy drugstore. -- Image credit: I Viewfinder |
© 2024 MJH Life Sciences

All rights reserved.