Daily OTC Pearl: Cetirizine (Zyrtec)


Zyrtec is an antihistamine with principal effects mediated via selective inhibition of peripheral H1 receptors.

OTC/Lifestyle Pearl of the Day: Cetirizine (Zyrtec)

Indication: For relief of nasal and ocular symptoms of seasonal and perennial allergic rhinitis; symptoms of chronic idiopathic urticaria.


  • Dosing:
    • Children from 2 to 6 years of age: 2.5 mg twice daily.
    • Children from 6 to 12 years of age: 5 mg twice daily.
    • Adolescents 12 years if age and above and adults: 10 mg once daily.
  • Contraindication: Zyrtec is contraindicated during lactation. Hypersensitivity to any of the constituents of the formulation, to hydroxyzine, or to any piperazine derivatives.
  • Adverse events include somnolence, fatigue, dizziness, and headache.
  • Mechanism of action: Cetirizine, a human metabolite of hydroxyzine, is an antihistamine. Its principal effects are mediated via selective inhibition of peripheral H1 receptors.
  • Manufacturer: Johnson and Johnson


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