Daily Medication Pearl: Tralokinumab-ldrm (Adbry)

Tralokinumab-ldrm is a human immunoglobulin G4 monoclonal antibody indicated for the treatment of moderate-to-severe atopic dermatitis.

Medication Pearl of the Day: Tralokinumab-ldrm (Adbry)

Indication: Tralokinumab-ldrm (Adbry) is an interleukin-13 (IL-13) antagonist indicated for the treatment of moderate-to-severe atopic dermatitis in adult patients whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

Insight:

  • Dosing: The recommended dosage of Adbry is an initial dose of 600 mg (four 150 mg injections), followed by 300 mg (two 150 mg injections) administered every other week.
  • Dosage forms: Injection 150 mg/mL solution in a single-dose prefilled syringe with needle guard.
  • Adverse events: Most common adverse events (incidence ≥ 1%) are upper respiratory tract infections, conjunctivitis, injection site reactions, and eosinophilia.
  • Mechanism of action: Tralokinumab-ldrm is a human immunoglobulin G4 monoclonal antibody that specifically binds to human IL-13 and inhibits its interaction with the IL-13 receptor α1 and α2 subunits.
  • Manufacturer: LEO Pharma

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