Daily Medication Pearl: Ponesimod (Ponvory)


Ponesimod (Ponvory) is indicated for the treatment of relapsing forms of multiple sclerosis.

Medication Pearl of the Day: Ponesimod (Ponvory)

Indication: Ponesimod (Ponvory) is a sphingosine 1-phosphate receptor modulator indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.


  • Dosing: The recommended maintenance dosage is 20 mg taken orally once daily.
  • Dosage forms: Tablets 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, and 20 mg.
  • Adverse events: Most common adverse reactions (incidence at least 10%) are upper respiratory tract infection, hepatic transaminase elevation, and hypertension.
  • Mechanism of action: Ponesimod is a sphingosine 1-phosphate (S1P) receptor 1 modulator that binds with high affinity to S1P receptor 1.
  • Manufacturer: Janssen Pharma


PONVORY-pi.pdf (janssenlabels.com)

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