Daily Medication Pearl: Midazolam (Nayzilam)

Midazolam is indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity that are distinct from a patient’s usual seizure pattern in patients with epilepsy.

Medication Pearl of the Day: Midazolam (Nayzilam)

Indication: Midazolam is a benzodiazepine indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 12 years of age and older.

Insight:

  • Dosing: For the initial dose, administer 1 spray (5 mg dose) into a nostril. If the patient does not respond to the initial dose after 10 minutes, administer 1 additional 5 mg dose into the opposite nostril.
  • Dosage form: Single-dose nasal spray unit containing 5 mg midazolam per 0.1 mL solution.
  • Adverse events (AEs): The most common AEs were somnolence, headache, nasal discomfort, throat irritation, and rhinorrhea.
  • Mechanism of action: The exact mechanism of action for midazolam is not fully understood, but it is thought to involve potentiation of GABAergic neurotransmission resulting from binding at the benzodiazepine site of the GABAa receptor
  • Manufacturer: UCB

Sources:

  1. NAYZILAM current COL - Rev. 05 February 2021 (ucb-usa.com)
  2. nayzilam - Google Search