Daily Medication Pearl: Mesalamine (Apriso)

Mesalamine (Apriso) is a locally acting aminosalicylate indicated to treat and prevent flare-ups of ulcerative colitis.

Medication Pearl of the Day: Mesalamine (Apriso)

Indication: Mesalamine (Apriso) is a locally acting aminosalicylate indicated for the maintenance of diarrhea, upper abdominal pain, nausea, nasopharyngitis, flu or flu-like remission of ulcerative colitis in adults.

Insight:

  • Dosing: Four capsules once daily (1.5 g/day) in the morning with or without food. Do not co-administer with antacids.
  • Dosage forms: Extended-release capsules 0.375 g.
  • Adverse events: The most common adverse reactions (incidence ≥3%) are headache, diarrhea, upper abdominal pain, nausea, nasopharyngitis, flu or flu-like remission of ulcerative colitis in adults, illness, and sinusitis.
  • Mechanism of action: The mechanism of action of mesalamine is unknown but appears to be local to the intestinal mucosa rather than systemic.
  • Manufacturer: Catalent Pharma

Sources:

label (fda.gov)

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