Daily Medication Pearl: Maralixibat (Livmarli) for Cholestatic Pruritus

Clinical Pearl of the Day: Maralixibat (Livmarli)

Maralixibat is an ileal bile acid transporter inhibitor indicated for the treatment of cholestatic pruritus in patients with Alagille syndrome 1 year of age and older.

Insight:

• Dosage: The recommended dosage is 380 mcg/kg once daily, taken 30 minutes before the first meal of the day. Starting dose is 190 mcg/kg orally once daily and should be increased to 380 mcg/kg once daily after 1 week, as tolerated.
• Dosing: Oral solution 9.5 mg of maralixibat per mL.
• Adverse events: Include diarrhea, abdominal pain, vomiting, fat-soluble vitamin deficiency, liver test abnormalities, gastrointestinal bleeding, and bone fractures.
• Mechanism of action: Maralixibat decreases the reabsorption of bile acids (primarily the salt forms) from the terminal ileum.
• Manufacturer: Mirum

Sources:

Approval [Rx ONLY] (mirumpharma.com)

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