Daily Medication Pearl: Cyclosporine Ophthalmic Solution (Cequa)


Cequa ophthalmic solution is indicated to increase tear production in patients with dry eyes.

Medication Pearl of the Day: Cyclosporine ophthalmic solution (Cequa)

Indication: Cequa ophthalmic solution is a calcineurin inhibitor immunosuppressant indicated to increase tear production in patients with keratoconjunctivitis sicca (dry eyes).


  • Dosing: Instill 1 drop of Cequa twice daily (approximately 12 hours apart) into each eye. Discard the vial immediately after using in both eyes.
  • Dosage forms: Ophthalmic solution containing cyclosporine 0.9 mg/mL.
  • Adverse events (AEs): The most common AEs reported in greater than 5% of subjects were pain on instillation of drops (22%) and conjunctival hyperemia (6%). Other AEs reported in 1% to 5% of the patients were blepharitis, eye irritation, headache, and urinary tract infection.
  • Mechanism of action: Cyclosporine is a calcineurin inhibitor immunosuppressant agent when administered systemically.
  • Manufacturer: Sun Pharma


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