Potential Drug-Drug Interactions With Psilocybin, MDMA, Ketamine

Kelan Thomas, PharmD, MS, associate professor of clinical sciences at Touro University California College of Pharmacy, discusses potential drug-drug interactions with psilocybin, MDMA, and ketamine to consider outside of interactions with psychiatric medications.

Pharmacy Times interviewed Kelan Thomas, PharmD, MS, associate professor of clinical sciences at Touro University California College of Pharmacy, on his recent presentations at Insight 2021 and the virtual Sana Symposium on psychedelic adverse effects and drug-drug interactions.

Alana Hippensteele: Are there other potential drug-drug interactions with psilocybin, MDMA, and ketamine to consider outside of interactions with psychiatric medications?

Kelan Thomas: Yeah, so MDMA, because of its broad metabolism by multiple different [cytochrome P450 (CYP)] enzymes, and, as I mentioned, its own autoinhibition, so it's also an inhibitor of CYP2D6 substrates, and so that's where I think you really would have to start to do drug interaction trials to get a sense of how much of a difference. But that's what I would be most concerned about is that MDMA could have interactions with a broad array of other drugs given it is a substrate of multiple CYP enzymes and it is also an inhibitor of CYP2D6.

Alana Hippensteele: Yeah, absolutely. Thank you so much for taking the time to speak with me today, Kelan.

Kelan Thomas: Sure, thank you.

Related Videos
Credit: wladimir1804 - stock.adobe.com
Women buying contraceptive pills in the pharmacy | Image credit: Antonioguillem - stock.adobe.com
Healthcare technology | Image credit: ipopba | stock.adobe.com
Gastroenterologist using digital x-ray of human intestine holographic scan projection 3D rendering | Image Credit: sdecoret - stock.adobe.com
Supreme Court | Image credit: steheap - stock.adobe.com
Pharmacists talking with a nurse | Image credit: Jacob Lund - stock.adobe.com
Healthcare technology | Image credit: ipopba | stock.adobe.com
Related Content
© 2023 MJH Life Sciences

All rights reserved.