Pharmacist Medication Insights: Prucalopride for Chronic Idiopathic Constipation


Unlike other medications for chronic idiopathic constipation, prucalopride works by enhancing colonic peristalsis to increase bowel motility.

In 2018, the FDA approved prucalopride (Motegrity, Shire) for the treatment of chronic idiopathic constipation (CIC).

According to Shire, an estimated 35 million adults are living with CIC, affecting roughly 14% of the adult population. Prucalopride, a selective serotonin-4 (5-HT4) receptor agonist, provides an oral treatment option for adults with the disease. Unlike other medications for CIC, prucalopride works by enhancing colonic peristalsis to increase bowel motility.

The approval was based on 6 clinical studies lasting 12 weeks or 24 weeks evaluating the efficacy of once-daily treatment with prucalopride in 2484 patients. In the studies, significantly more patients receiving prucalopride achieved the primary endpoint, an average of ≥3 complete spontaneous bowel movements per week over 12 weeks, than those who received a placebo. The studies also showed a rapid response with prucalopride treatment in as early as week 1, with improvements maintained throughout 12 weeks of treatment.

Related Videos
Pharmacy Drugstore Checkout Cashier Counter: Beautiful Female Pharmacist Scans Barcode and Handsome Young Man Talks to a Cashier and Pays for the Health Care Products at the Checkout Counter - Image credit: Gorodenkoff |
Image Credit: Adobe Stock - nataliaderiabina
Credit: Adobe Stock - Tierney
ipopba -
lexiconimages -
Yaruniv-Studio -
Medical hands holds syringe and vaccine | Image Credit: Alernon77
Related Content
© 2023 MJH Life Sciences

All rights reserved.