Daily OTC Pearl: Cystex for Urinary Tract Infection

Cystex provides prophylaxis for urinary tract infections.

OTC/Lifestyle Pearl of the Day: Cystex

Indication: Cystex is used for urinary tract infection (UTI) prophylaxis.

Insight:

  • Dosage: 162 mg/162.5 mg/32 mg
  • Dosing: 2 tablets PO q12hr
    • Administer with meals and at bedtime.
    • Use only after eradication of UTI by other appropriate antibiotic.
  • Ingredients:
    • Methenamine: Indicated for prophylaxis/suppression for chronic recurring UTIs when long-term therapy is required.
    • Sodium salicylate: Analgesic.
    • Benzoic acid: Elicits weak antifungal and antibacterial properties; also helps acidify urine.
  • Adverse events: Dysuria, gastric upset, nausea, and rash.
  • Warning: Methenamine is excreted in human milk; caution advised, risk to infant cannot be ruled out.
  • Mechanism of action:
    • Methenamine: Hydrolyzed in acidic urine to ammonia and formaldehyde, which are bactericidal agents. Does not convert to formaldehyde in serum.
    • Sodium salicylate: Analgesic
    • Benzoic acid: Elicits weak antifungal and antibacterial properties; also helps acidify urine.

Sources:

Cystex (methenamine/sodium salicylate/benzoic acid) dosing, indications, interactions, adverse effects, and more. (medscape.com)