Daily Medication Pearl: Ondansetron Hydrochloride (Zofran)

Medication Pearl of the Day: Ondansetron Hydrochloride (Zofran)

Indication: Zofran is a 5-HT3 receptor antagonist indicated for the prevention of nausea and vomiting.

Insight:

• Dosing: Take 1 tablet every day or as needed prescribed by the provider.
• Dosage forms: Tablets 4 mg and 8 mg (orally disintegrating tablets available), oral solution 4 mg/5 mL.
• Adverse events (AEs): The most common AEs in adults are headache, malaise/fatigue, constipation, and diarrhea.
• Mechanism of action: Ondansetron is a selective 5-HT3 receptor antagonist.
• Manufacturer: GSK

Sources:

ZOFRAN (ondansetron hydrochloride) Label (fda.gov)

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