Daily Medication Pearl: Ondansetron Hydrochloride (Zofran)

Zofran aids in the prevention of nausea and vomiting.

Medication Pearl of the Day: Ondansetron Hydrochloride (Zofran)

Indication: Zofran is a 5-HT3 receptor antagonist indicated for the prevention of nausea and vomiting.


  • Dosing: Take 1 tablet every day or as needed prescribed by the provider.
  • Dosage forms: Tablets 4 mg and 8 mg (orally disintegrating tablets available), oral solution 4 mg/5 mL.
  • Adverse events (AEs): The most common AEs in adults are headache, malaise/fatigue, constipation, and diarrhea.
  • Mechanism of action: Ondansetron is a selective 5-HT3 receptor antagonist.
  • Manufacturer: GSK


ZOFRAN (ondansetron hydrochloride) Label (fda.gov)

zofran image - Google Search