Daily Medication Pearl: Hyqvia Immune Globulin Infusion 10%

Article

Hyqvia is an immune globulin with a recombinant human hyaluronidase indicated for the treatment of primary immunodeficiency in adults.

Medication Pearl of the Day: Hyqvia Immune Globulin Infusion 10%

Indication: Hyqvia is an immune globulin with a recombinant human hyaluronidase indicated for the treatment of primary immunodeficiency (PI) in adults.

Insight:

  • Dosing: May start from 7.5 g up to 30 g infusions depending on the patient.
  • Dosage forms: Comes in 10%, 2.5, 5-, 10-, 20-, and 30-gram proteins.
  • Adverse events: The most common adverse reactions observed in clinical trials in >5% of subjects were local reactions, headache, antibody formation against recombinant human hyaluronidase (rHuPH20), fatigue, nausea, pyrexia, and vomiting.
  • Mechanism of action: The immune globulin infusion 10% (human) provides the therapeutic effect of Hyqvia. The recombinant human hyaluronidase of Hyqvia increases dispersion and absorption of the immune globulin infusion 10% (human). The immune globulin infusion 10% (human) of Hyqvia supplies a broad spectrum of opsonizing and neutralizing IgG antibodies against a wide variety of bacterial and viral agents.

Source: HYQVIA [Immune Globulin Infusion 10% (Human) with Recombinant (fda.gov)

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